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・ Manuel Díaz (fencer)
・ Manuel Díaz Gil
・ Manuel Díaz Montava
・ Manuel Díaz Rodríguez
・ Manuel Díaz Vega
・ Manuel Díez Cabral
・ Manuel E. Machado
・ Manuel Earnshaw
・ Manuel Echauri
・ Manuel Echeverría
・ Manuel Echezarreta
・ Manuel Eduardo de Gorostiza
・ Manuel Egozcue Cintrón
・ Manuel Eguiguren Galarraga
・ Manuel Eisner
Manuel Elkin Patarroyo
・ Manuel Enrique Araujo
・ Manuel Enrique Ovalle Araiza
・ Manuel Enríquez
・ Manuel Enríquez Rosero
・ Manuel Erotikos Komnenos
・ Manuel Escorcio
・ Manuel Esparza
・ Manuel Esperón
・ Manuel Espino Barrientos
・ Manuel Espinosa
・ Manuel Espinosa Batista
・ Manuel Esquivel
・ Manuel Esteba
・ Manuel Estiarte


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Manuel Elkin Patarroyo : ウィキペディア英語版
Manuel Elkin Patarroyo

Manuel Elkin Patarroyo (born November 3, 1946)〔Fundación Príncipe de Asturias. (Manuel Elkin Patarroyo ) (Spanish). Premiados, Investigación Científica y Técnica, 1994.〕 is a Colombian Professor of Pathology and Immunology who made the world's first attempt to create a synthetic vaccine against a parasite called the protozoa Plasmodium falciparum that causes severe malaria,〔Holloway, M. (1996) ''Profile: Manuel Elkin Patarroyo – The Man Who Would Conquer Malaria'', Scientific American 275(6), 52-56.〕 a disease transmitted by mosquitoes that affects millions of people and is one of the leading causes of death (~1.5 million people per year) in tropical and subtropical regions, including parts of the Americas, Asia, and Africa.
The vaccine candidate, first developed in 1987 in Colombia, was evaluated in clinical trials carried out by the WHO in Gambia, Tanzania and Thailand, and had mixed results.〔- Susan Aldridge, ''Magic Molecules: How Drugs Work'' (Cambridge University Press, 1998), p. 89〕 In 2009, a comprehensive Cochrane review assessed the SPf66 as being not efficacious in Africa and Asia, and as having a low but statistically significant efficacy of 28% in South America.〔- (Graves, P. M. and Gelband, H. (2009) Vaccines for preventing malaria (SPf66) (Review), The Cochrane Library 2009, (2), pp.1-38. )〕 Today, after more than 33 years of research, there is still however no licensed malaria vaccine. Researchers and vaccine developers have been working on many approaches to bring forward the availability of a malaria vaccine."〔- (WHO (2010) Tables of Malaria Vaccine Projects Globally (Updated December 2010), Initiative for Vaccine Research. )〕 More research and clinical trials are required for a universal vaccine to be implemented.
==References==


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